A suspension of colloidal particles, with anisotropic surface features, often referred to as Janus particles, behaves distinctly from a suspension of their isotropic counterparts both in the absence and presence of external flows or fields. The asymmetrical interparticle interactions—caused by the anisotropic surface features—and the particle concentration change the classic observations of colloidal suspensions rheology expected. My research is focused on study structure formation, diffusion and rheology of Janus particle suspensions via theory and Brownian/Stokesian dynamic methods. Understanding the rheology of these suspensions under external stress could provide insight on how to handle these materials and tailor their properties for current emerging technologies.