Samudra Sengupta, Debabrata Patra, Isamar Ortiz-Rivera, Arjun Agrawal, Sergey Shklyaev, Krishna K. Dey, Ubaldo Córdova-Figueroa, Thomas E. Mallouk & Ayusman Sen
Published online: 30 March 2014 | doi:10.1038/nchem.1895
Self-powered micropumps that are turned on by the presence of their respective substrates are formed from surface-immobilized, ATP-independent enzymes. Coupling substrate-sensing with transport enables the design of devices that deliver cargo in response to specific stimuli. Demonstrated here is the release of insulin at a rate proportional to ambient glucose concentration.